Listen here: https://idiotspodcasting.buzzsprout.com/1782416/episodes/10848117-24-ambl-er-ing-through-beta-lactamases
Definitions:
- Beta lactamase: Hydrolytic enzyme that acts on a beta lactam to cleave the beta-lactam ring
- ESBL Extended spectrum beta lactamase
- CRO - carbapenem resistant organism (any bug, any mechanism)
- CPO - carbapenemase producing organism (any bug, carbapenemase)
- CRE – carbapenem resistant enterobacterales (Enterobacterales, any mechanism)
- CPE - carbapenemase producing enterobacterales (Enterobacterales, carbapenemase)
This elegantly drawn diagram explains the differences:
Look, don’t judge me, I’m a podcaster not an artist.
History of resistance
How Resistance mechanisms spread in the population:
