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https://idiotspodcasting.buzzsprout.com/1782416/episodes/16509603-108-the-yeasts-candida-part-1-overview-and-superficial-candidiasis

https://idiotspodcasting.buzzsprout.com/1782416/episodes/16510075-109-the-yeasts-candida-part-2-candidaemia-and-invasive-disease

https://idiotspodcasting.buzzsprout.com/1782416/episodes/17057489-110-the-yeasts-candida-part-3-c-auris-and-candida-resistance

• Guest speaker Professor Tihana Bicanic

Candida spp.

• Candidiasis is the most common human fungal infection
• Candida spp. cause both superficial infection (cutaneous, mucosal) and invasive disease (candidaemia, deep-seated)
• C. albicans is responsible for about 90% of human Candida infections and 40-50% of cases of candidaemia
• Non-albicans Candida spp. include C. glabrata, C. parapsilosis, C. tropicalis, C. krusei, C. auris, C. lusitaniae, C. guilliermondii, C. dubliniensis
• There has been a noticeable increase in non-albicans Candida spp. causing infection in recent years → C. glabrata now accounts for 28% of candidaemia in England and C. parapsilosis 12%
• Invasive candidiasis is associated with high mortality: 10-47% for candidaemia and > 50% for endocarditis

Taxonomy

Epidemiology

• Candida spp., and species previously in the genus Candida, are common commensal organisms of human skin and GI tract
• Candida spp. cause opportunistic infection in the context immunocompromise, antibiotic usage or other factors that promote Candida growth