It’s A Breakpoints Breakout!

Breakpoints Breakout_v3.mp3

Previous podcast episodes on DTR Gram negatives

What’s DTR?

IDSA Guidance 2024

• Updated yearly (last 12 July 2024): https://doi.org/10.1093/cid/ciae403

• Differences from ESCMID 2022:

  

• And of course: it’s updated annually!

3rd Generation Cephalosporin Resistance

NB: We need to talk about MERINO

ESBL

• Definition: Ceftriaxone MIC ≥2

  

• Also: avoid oral step-down to:

  • Nitrofurantoin
  • Fosfomycin
  • Amoxicillin-clavulanate
  • Doxycycline & Omadacycline

• Questions for Breakpoints:

AmpC

• Mechanisms of increased AmpC production: